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在伴有早期妊娠丢失的女性中，存在血栓调节蛋白时，凝血酶生成增加。

Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss.

机构信息

Department of Internal Medicine and Chest Diseases, Brest University Hospital, La Cavale Blanche Hospital, Brest, France.

出版信息

Fertil Steril. 2011 Apr;95(5):1813-5.e1. doi: 10.1016/j.fertnstert.2010.11.019. Epub 2010 Dec 3.

DOI:10.1016/j.fertnstert.2010.11.019
PMID:21130429
Abstract

Compared with 537 parous controls with no history of pregnancy loss, a lower thrombomodulin-related inhibition of the endogenous thrombin potential was measured in 264 cases with previous unexplained pregnancy loss, especially when losses occurred between 9 and 12 weeks of gestation. Adjusting age, protein S, factor VIII, factor V Leiden, and prothrombin G20210A did not change the results.

摘要

与 537 名无妊娠丢失史的经产妇对照相比，264 例不明原因妊娠丢失患者的血栓调节蛋白相关内源性凝血酶潜能抑制作用较低，尤其是当流产发生在妊娠 9-12 周时。调整年龄、蛋白 S、因子 VIII、因子 V Leiden 和凝血酶原 G20210A 并不改变结果。

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