Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, Guangzhou, Guangdong Province, China.
J Neuroimmunol. 2011 Apr;233(1-2):181-4. doi: 10.1016/j.jneuroim.2010.11.004. Epub 2010 Dec 4.
To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese.
Thirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based typing (SBT).
The frequency of the DRB1 0901 was lower in NMO patients than in CTLs (P(uncorr)=0.022, OR: 0.194, 95% CI: 0.043-0.876), and DRB1 1602 was higher in NMO patients than in C-MS (P(uncorr)=0.038, OR: 3.491, 95% CI: 1.024-11.896) and CTLs (P(uncorr)=0.051, OR: 2.711, 95% CI: 0.971-7.556). The frequency of DPB1 0501 was significant higher in NMO patients than in C-MS (P(uncorr)=0.018, OR: 4.629, 95% CI: 1.235-17.350) and CTLs (P(uncorr)=0.001, P(corr)=0.022, OR: 7.096, 95% CI: 2.011-25.044).
DPB1 0501 correlates with risk of AQP4-Ab positive NMO in Southern Han Chinese.
分析人类白细胞抗原（HLA）-DRB1 和 -DPB1 等位基因在南方汉族人群中视神经脊髓炎（NMO）和多发性硬化（MS）发病机制中的作用。
纳入 30 例血清抗水通道蛋白 4 抗体（AQP4-Ab）阳性的 NMO 患者、53 例传统多发性硬化（C-MS）患者和 93 例对照者（CTLs）。采用测序基序（SBT）法检测研究对象的 HLA-DRB1 和 -DPB1 等位基因。
NMO 患者中 HLA-DRB1 0901 频率低于 CTLs（P（未校正）=0.022，OR：0.194，95%CI：0.043-0.876），而 HLA-DRB1 1602 在 NMO 患者中高于 C-MS（P（未校正）=0.038，OR：3.491，95%CI：1.024-11.896）和 CTLs（P（未校正）=0.051，OR：2.711，95%CI：0.971-7.556）。NMO 患者中 HLA-DPB1 0501 频率明显高于 C-MS（P（未校正）=0.018，OR：4.629，95%CI：1.235-17.350）和 CTLs（P（未校正）=0.001，P（校正）=0.022，OR：7.096，95%CI：2.011-25.044）。
DPB1 0501 与南方汉族人群中 AQP4-Ab 阳性 NMO 的风险相关。
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