Department of Clinical Medicine, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil.
Alcohol. 2011 Mar;45(2):123-9. doi: 10.1016/j.alcohol.2010.08.011. Epub 2010 Dec 4.
Arrhythmogenic effects of alcohol may be intermediated by its effects over heart rate variability (HRV). Most studies about the effects of alcohol over HRV were observational and did not explore the temporal influence of alcohol ingestion over autonomic modulation. The aim of this study was to verify if an acute ingestion of alcohol has a time-dependent influence over time-domain indices of HRV. The effect of the ingestion of 60 g of ethanol or placebo over autonomic modulation was compared in healthy men (35 per group), with 18-25 years of age, before and during 17 h after ingestion. Alcohol promoted a fall in the standard deviation of all normal R-R intervals, root mean square of successive differences, and percentage of pairs of adjacent R-R intervals differing by more than 50 ms and in two indices of the three-dimensional return map, by a period up to 10 h after the ingestion of alcohol, accompanied by an increase in heart rate. The indices returned to values similar of the control group 10 h after ingestion. The effects over HRV indices were attenuated by adjustment for heart rate. The ingestion of alcohol induces a broad cardiovascular adaptation secondary to vagal withdrawal and sympathetic activation that may be responsible for arrhythmogenic effects of alcohol ingestion.
酒精的致心律失常作用可能与其对心率变异性（HRV）的影响有关。大多数关于酒精对 HRV 影响的研究都是观察性的，并未探讨酒精摄入对自主神经调节的时间影响。本研究旨在验证急性饮酒是否对 HRV 的时域指数有时间依赖性影响。在摄入前和摄入后 17 小时内，将 60 克乙醇或安慰剂分别给予 18-25 岁的健康男性（每组 35 人），比较其对自主神经调节的影响。酒精摄入可导致所有正常 R-R 间期的标准差、连续差值的均方根和相差 50 毫秒以上的相邻 R-R 间期对的百分比以及三维返回映射的两个指数下降，直至酒精摄入后 10 小时，同时心率增加。摄入后 10 小时，这些指数恢复到与对照组相似的值。通过对心率进行调整，可减弱对 HRV 指数的影响。酒精摄入引起广泛的心血管适应，继发于迷走神经撤退和交感神经激活，这可能是酒精摄入致心律失常作用的原因。
