Liu Xiaowei, Cui Yi, Ouyang Chunhui, Li Xuefeng, Lu Fanggen, Wu Xiaoping
Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Nov;35(11):1196-200. doi: 10.3969/j.issn.1672-7347.2010.11.014.
To analyze the characteristics of intestinal flora in Crohn's disease (CD) and intestinal tuberculosis (ITb), and to find potential identification features to differentiate these 2 diseases.
Fifteen CD patients, 23 ITb patients, and 21 healthy volunteers (controls) were enrolled from June 2007 to November 2009. Selective culturing was used for the enumeration of bacteria count.
The intestinal flora was mainly composed of Bifidobacteria, Bacteroids, Escherichia coli and Staphylococcus aureus both in CD and ITb patients. Lactobacillus and Bifidobacteria decreased obviously but Bacteroid increased in CD patients compared with the control (P<0.01). Lactobacillus, Bifidobacteria and Escherichia coli decreased obviously (P<0.05), but Bacteroid increased in ITb patients compared with the control (P<0.01). Bacteroid increased in ITb patients compared with CD patients (P<0.05). No difference in Enterococcus, Staphylococcus aureus and Saccharomycete was found among the 3 groups (P>0.05).
Intestinal flora disorder occurred in either CD or ITb patients. The alteration of Bacteroid and Escherichia coli can help differentiate the 2 diseases.
分析克罗恩病（CD）和肠结核（ITb）患者肠道菌群的特征，寻找可用于鉴别这两种疾病的潜在特征。
选取2007年6月至2009年11月期间的15例CD患者、23例ITb患者和21名健康志愿者（对照组）。采用选择性培养法对细菌数量进行计数。
CD患者和ITb患者的肠道菌群均主要由双歧杆菌、拟杆菌、大肠杆菌和金黄色葡萄球菌组成。与对照组相比，CD患者的乳酸杆菌和双歧杆菌明显减少，但拟杆菌增加（P<0.01）。与对照组相比，ITb患者的乳酸杆菌、双歧杆菌和大肠杆菌明显减少（P<0.05），但拟杆菌增加（P<0.01）。与CD患者相比，ITb患者的拟杆菌增加（P<0.05）。三组间肠球菌、金黄色葡萄球菌和酵母菌无差异（P>0.05）。
CD患者和ITb患者均存在肠道菌群紊乱。拟杆菌和大肠杆菌的变化有助于鉴别这两种疾病。
