[克罗恩病与肠结核肠道菌群的特征及鉴别诊断]

[Characteristics and differential diagnosis of intestinal flora in Crohn's disease and intestinal tuberculosis].

作者信息

Liu Xiaowei, Cui Yi, Ouyang Chunhui, Li Xuefeng, Lu Fanggen, Wu Xiaoping

机构信息

Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Nov;35(11):1196-200. doi: 10.3969/j.issn.1672-7347.2010.11.014.

DOI:10.3969/j.issn.1672-7347.2010.11.014

PMID:21131744

Abstract

OBJECTIVE

To analyze the characteristics of intestinal flora in Crohn's disease (CD) and intestinal tuberculosis (ITb), and to find potential identification features to differentiate these 2 diseases.

METHODS

Fifteen CD patients, 23 ITb patients, and 21 healthy volunteers (controls) were enrolled from June 2007 to November 2009. Selective culturing was used for the enumeration of bacteria count.

RESULTS

The intestinal flora was mainly composed of Bifidobacteria, Bacteroids, Escherichia coli and Staphylococcus aureus both in CD and ITb patients. Lactobacillus and Bifidobacteria decreased obviously but Bacteroid increased in CD patients compared with the control (P<0.01). Lactobacillus, Bifidobacteria and Escherichia coli decreased obviously (P<0.05), but Bacteroid increased in ITb patients compared with the control (P<0.01). Bacteroid increased in ITb patients compared with CD patients (P<0.05). No difference in Enterococcus, Staphylococcus aureus and Saccharomycete was found among the 3 groups (P>0.05).

CONCLUSION

Intestinal flora disorder occurred in either CD or ITb patients. The alteration of Bacteroid and Escherichia coli can help differentiate the 2 diseases.

摘要

目的

分析克罗恩病（CD）和肠结核（ITb）患者肠道菌群的特征，寻找可用于鉴别这两种疾病的潜在特征。

方法

选取2007年6月至2009年11月期间的15例CD患者、23例ITb患者和21名健康志愿者（对照组）。采用选择性培养法对细菌数量进行计数。

结果

CD患者和ITb患者的肠道菌群均主要由双歧杆菌、拟杆菌、大肠杆菌和金黄色葡萄球菌组成。与对照组相比，CD患者的乳酸杆菌和双歧杆菌明显减少，但拟杆菌增加（P<0.01）。与对照组相比，ITb患者的乳酸杆菌、双歧杆菌和大肠杆菌明显减少（P<0.05），但拟杆菌增加（P<0.01）。与CD患者相比，ITb患者的拟杆菌增加（P<0.05）。三组间肠球菌、金黄色葡萄球菌和酵母菌无差异（P>0.05）。