McGhee Laura L, Slater Terry M, Garza Thomas H, Fowler Marcie, DeSocio Peter A, Maani Christopher V
US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA.
J Burn Care Res. 2011 Jan-Feb;32(1):46-51. doi: 10.1097/BCR.0b013e318204b359.
Early acute pain after injury has been linked to long-term patient outcomes, including the development of posttraumatic stress disorder (PTSD). Several studies have identified a negative correlation between early anesthetic/analgesic usage and subsequent development of PTSD. This retrospective study examined the relationship between early acute pain and severity of PTSD symptoms in soldiers with burn injuries. Of the soldiers injured in Overseas Contingency Operations who had pain scores recorded at admission to the Emergency Department, 113 had burn injuries. Of those transferred to the military burn center, 47 were screened for PTSD using the PTSD checklist-military (PCL-M) survey at least 1 month after injury. Soldiers with mild, moderate, and severe pain scores had similar Injury Severity Scores and TBSA burned (P = .339 and .570, respectively). However, there were significant differences in PCL-M scores between the mild and severe pain groups (P = .017). The pain levels positively correlated with the PCL-M score (rho = 0.41, P = .004) but not with injury severity markers (Injury Severity Score and TBSA). These data suggest that early acute pain may be related to increased PCL-M score and PTSD symptoms. The intensity of pain was not related to the injury severity, and these data also show no association between pain intensity and physiological measures, including blood pressure and heart rate. However, this is a small sample size, and many other factors likely influence PTSD development. Further study is necessary to explore the relationship between early acute pain and subsequent development of PTSD symptoms.
损伤后的早期急性疼痛与患者的长期预后相关,包括创伤后应激障碍(PTSD)的发生。多项研究已确定早期麻醉/镇痛药物的使用与PTSD的后续发生之间存在负相关。这项回顾性研究调查了烧伤士兵早期急性疼痛与PTSD症状严重程度之间的关系。在海外应急行动中受伤且在急诊科入院时记录了疼痛评分的士兵中,113人有烧伤。在转至军事烧伤中心的患者中,47人在受伤至少1个月后使用PTSD检查表-军事版(PCL-M)进行了PTSD筛查。轻度、中度和重度疼痛评分的士兵具有相似的损伤严重程度评分和烧伤总面积(分别为P = 0.339和0.570)。然而,轻度和重度疼痛组之间的PCL-M评分存在显著差异(P = 0.017)。疼痛程度与PCL-M评分呈正相关(rho = 0.41,P = 0.004),但与损伤严重程度指标(损伤严重程度评分和烧伤总面积)无关。这些数据表明,早期急性疼痛可能与PCL-M评分升高和PTSD症状有关。疼痛强度与损伤严重程度无关,这些数据还表明疼痛强度与包括血压和心率在内的生理指标之间没有关联。然而,这是一个小样本,许多其他因素可能影响PTSD的发生。有必要进一步研究以探讨早期急性疼痛与PTSD症状后续发生之间的关系。