Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
Otol Neurotol. 2011 Jan;32(1):147-51. doi: 10.1097/MAO.0b013e318200a0e0.
To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease.
Twelve temporal bones from 6 patients with bilateral Ménière's disease, 44 temporal bones from 23 patients with unilateral Ménière's disease, and 102 age-matched normal temporal bones from 56 individuals were histopathologically examined. The thickness of the round window membrane was calculated from 3 different places. In addition, the presence of false round window membrane was investigated in temporal bones with Ménière's disease and compared to the normal temporal bones.
A significant difference in the mean thickness of the round window membrane was observed in temporal bones with Ménière's disease compared with normal temporal bones. There was no significant difference in the thickness of the round window membrane between the diseased side and contralateral side in patients with unilateral Ménière's disease. A false round membrane was observed in 9 (25.7%) of 35 Ménière's disease cases and in 5 (4.9%) of 102 normal temporal bones.
The thickened nature of the round window membrane and the frequent presence of false round window membrane in patients with Ménière's disease may impede the intratympanic injection treatments. The thickened middle layer of the round window membrane may be related to perilymphatic pressure changes observed in patients with Ménière's disease.
揭示梅尼埃病中圆窗膜厚度的组织病理学发现和假圆窗膜的存在。
对 6 例双侧梅尼埃病患者的 12 个颞骨、23 例单侧梅尼埃病患者的 44 个颞骨和 56 名年龄匹配的正常个体的 102 个颞骨进行了组织病理学检查。从 3 个不同部位计算圆窗膜的厚度。此外，还研究了梅尼埃病患者颞骨中假圆窗膜的存在情况，并与正常颞骨进行了比较。
与正常颞骨相比，梅尼埃病患者的圆窗膜平均厚度存在显著差异。单侧梅尼埃病患者患侧与对侧圆窗膜厚度无显著差异。在 35 例梅尼埃病病例中有 9 例（25.7%）观察到假圆膜，在 102 例正常颞骨中有 5 例（4.9%）观察到假圆膜。
梅尼埃病患者圆窗膜增厚和假圆窗膜的频繁出现可能会妨碍鼓室内注射治疗。圆窗膜中层的增厚可能与梅尼埃病患者观察到的外淋巴液压力变化有关。
