分化良好的神经内分泌肿瘤：综述涵盖基本原理、局部区域和靶向治疗。
Well-differentiated neuroendocrine tumors: a review covering basic principles to loco-regional and targeted therapies.
机构信息
Department of Surgery, The Ohio State University, Columbus, OH, USA.
出版信息
Oncogene. 2011 Mar 31;30(13):1497-505. doi: 10.1038/onc.2010.548. Epub 2010 Dec 6.
Abstract
Neuroendocrine tumors (NETs) are a complex group of malignancies with variable prognosis and response to treatment. For pancreatic neuroendocrine and carcinoid tumors, traditional cytotoxic chemotherapies have demonstrated minimal activity. Current approaches for treatment of metastatic disease use a combination of loco-regional and targeted biological therapies. Clinical trials remain critical for evaluation of new and promising therapeutic options for patients with NETs.
摘要
神经内分泌肿瘤（NETs）是一组预后和对治疗反应各异的恶性肿瘤。对于胰腺神经内分泌和类癌肿瘤，传统细胞毒化疗显示出最小的活性。目前治疗转移性疾病的方法是联合局部区域和靶向生物治疗。临床试验对于评估 NET 患者新的和有前途的治疗选择仍然至关重要。
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