Wang Chih-Hong, Li Feng, Takahashi Nobuyuki
Department of Pathology and Laboratory Medicine The University of North Carolina at Chapel Hill Chapel Hill, NC 27599-7525.
Open Hypertens J. 2010;3:1-13. doi: 10.2174/1876526203010001.
The renin angiotensin system (RAS) is important for fluid and blood pressure regulation. Recent studies suggest that an overactive RAS is involved in the metabolic syndrome. This article discusses recent advances on how genetic alteration of the RAS affects cardiovascular and metabolic phenotypes, with a special emphasis on the potential role of angiotensin-independent effects of renin.
肾素血管紧张素系统（RAS）对体液和血压调节至关重要。最近的研究表明，过度活跃的RAS与代谢综合征有关。本文讨论了RAS基因改变如何影响心血管和代谢表型的最新进展，特别强调了肾素非血管紧张素依赖性效应的潜在作用。
