Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Integrative Complementary Alternative Medicine Research, Khon Kaen University, Khon Kaen 40002, Thailand.
Oxid Med Cell Longev. 2019 Nov 11;2019:5972575. doi: 10.1155/2019/5972575. eCollection 2019.
Due to the antimetabolic syndrome effect of mulberry and ginger together with the advantages of the synergistic effect and phytosome encapsulation technique, we hypothesized that phytosome containing the combined extracts of mulberry and ginger (PMG) should be able to manage MetS. PMG was developed and assessed the phenolic content and biological activities associated with the pathophysiology of MetS. The antimetabolic syndrome effect and the possible underlying mechanisms in the animal model of MetS were also assessed. Male Wistar rats induced MetS by subjecting to a 16-week high-carbohydrate high-fat diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg/kg for 21 days. They were determined metabolic parameter changes in serum, histomorphology changes of adipose tissue, the inflammatory cytokines such as IL-6 and TNF-, oxidative stress status, PPAR-, and HDAC3 in adipose tissue. Our data showed that PMG increased phenolic contents and biological activities. PMG significantly improved MetS parameters including body weight gain, lipid profiles, plasma glucose, HOMA-IR, and ACE. In addition, the density and size of adipocyte, adiposity index, and weights of adipose tissues were also improved. Moreover, the decrease in TNF- and IL-6, oxidative stress status, and HDAC3 expression together with the increase in PPAR- expression in adipose tissue was also observed. These data suggest that PMG exhibit antimetabolic syndrome and the possible underlying mechanism may be associated partly with the modulation effect on HDAC3, PPAR-, and adipose tissue. In addition, PMG also improves oxidative stress and inflammation in MetS. Therefore, PMG can be served as the potential supplement to manage MetS. However, a clinical trial study is essential to confirm this health benefit.
由于桑椹和姜的抗代谢综合征作用以及协同作用和植物素包封技术的优势，我们假设含有桑椹和姜的联合提取物的植物素（PMG）应该能够治疗代谢综合征。开发了 PMG 并评估了与代谢综合征病理生理学相关的酚类含量和生物活性。还评估了代谢综合征动物模型中的抗代谢综合征作用和可能的潜在机制。雄性 Wistar 大鼠通过给予 16 周高碳水化合物高脂肪饮食来诱导代谢综合征。代谢综合征大鼠每天口服给予 PMG，剂量为 50、100 和 200mg/kg，持续 21 天。他们测定了血清中的代谢参数变化、脂肪组织的组织形态变化、IL-6 和 TNF-等炎症细胞因子、氧化应激状态、脂肪组织中的 PPAR-和 HDAC3。我们的数据表明，PMG 增加了酚类含量和生物活性。PMG 显著改善了代谢综合征参数，包括体重增加、脂质谱、血浆葡萄糖、HOMA-IR 和 ACE。此外，还改善了脂肪细胞的密度和大小、肥胖指数和脂肪组织的重量。此外，还观察到 TNF-和 IL-6、氧化应激状态和 HDAC3 表达的降低以及脂肪组织中 PPAR-表达的增加。这些数据表明，PMG 表现出抗代谢综合征作用，其潜在机制可能部分与对 HDAC3、PPAR-和脂肪组织的调节作用有关。此外，PMG 还改善了代谢综合征中的氧化应激和炎症。因此，PMG 可以作为治疗代谢综合征的潜在补充剂。然而，需要进行临床试验研究来确认这种健康益处。
