Paudel Kalpana S, Milewski Mikolaj, Swadley Courtney L, Brogden Nicole K, Ghosh Priyanka, Stinchcomb Audra L
College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA.
Ther Deliv. 2010 Jul;1(1):109-31. doi: 10.4155/tde.10.16.
Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.
经皮给药是一个令人兴奋且具有挑战性的领域。目前市场上有众多经皮给药系统。然而，经皮给药市场仍然局限于种类有限的药物。经皮给药的进一步发展取决于能否克服药物分子渗透和皮肤刺激性方面所面临的挑战。新型皮肤渗透增强技术的出现以及减轻皮肤刺激方法的开发将拓宽亲水性化合物、大分子和用于新治疗适应症的传统药物的经皮给药市场。从针对各种临床病症的多种药物正在进行的临床试验中可以明显看出，药物经皮给药有着广阔的前景。
