Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany.
Horm Metab Res. 2010 Dec;42(13):912-7. doi: 10.1055/s-0030-1268457. Epub 2010 Dec 3.
Within the last couple of years much knowledge has been gained in understanding the immune interactions in endocrine diseases including endocrine malignancies and autoimmune diseases. The major players within the innate immune system represent NK cells. This review describes that these cells directly lyse tumor cells and promote the activity of other cells of the immune system, including dendritic cells (DCs), macrophages, Th1 cells, and cytotoxic T-lymphocytes (CTLs). NK cells may also be involved in the initiation of autoimmunity as they may accumulate in target organs of certain autoimmune diseases. On the other hand, there are cells of the adaptive immune system including antigen-presenting DCs and T cells with helper and effector function, which are responsible for a directed immune response. Within this review, we present an overview on the role of all these cell populations in endocrine disease and the potential use of such cells for immunotherapy in different endocrine diseases and refer to experimental settings as well as clinical studies.
在过去的几年中，人们对内分泌疾病（包括内分泌恶性肿瘤和自身免疫性疾病）中的免疫相互作用有了更多的了解。先天免疫系统中的主要参与者是自然杀伤 (NK) 细胞。这篇综述描述了这些细胞可以直接溶解肿瘤细胞，并促进免疫系统其他细胞的活性，包括树突状细胞 (DC)、巨噬细胞、Th1 细胞和细胞毒性 T 淋巴细胞 (CTL)。NK 细胞也可能参与自身免疫的发生，因为它们可能在某些自身免疫性疾病的靶器官中积累。另一方面，适应性免疫系统包括具有辅助和效应功能的抗原呈递树突状细胞和 T 细胞，它们负责定向免疫反应。在这篇综述中，我们概述了所有这些细胞群体在内分泌疾病中的作用，以及它们在不同内分泌疾病的免疫治疗中的潜在用途，并提到了实验设置和临床研究。
