淀粉样β蛋白前体与细胞外基质相关。
Amyloid beta-protein precursor is associated with extracellular matrix.
作者信息
Klier F G, Cole G, Stallcup W, Schubert D
机构信息
La Jolla Cancer Research Foundation, CA.
出版信息
Brain Res. 1990 May 7;515(1-2):336-42. doi: 10.1016/0006-8993(90)90619-m.
PMID:2113416
Abstract
The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
摘要
研究了淀粉样β蛋白前体（ABPP）在一种神经元细胞系培养物中的超微结构分布。ABPP与这些细胞分泌的大量细胞外基质（ECM）相关。讨论了与基质相关的ABPP在阿尔茨海默病发病机制中的可能作用。
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