将促甲状腺激素释放激素注入大鼠杏仁核中央核会诱发胃部损伤。

Administration of thyrotropin-releasing hormone into the central nucleus of the amygdala induces gastric lesions in rats.

作者信息

Hernandez D E, Salaiz A B, Morin P, Moreira M A

机构信息

Division of Gastroenterology, University of Southern California, School of Medicine, Los Angeles 90033.

出版信息

Brain Res Bull. 1990 May;24(5):697-9. doi: 10.1016/0361-9230(90)90010-w.

DOI:10.1016/0361-9230(90)90010-w

PMID:2113419

Abstract

Studies utilizing microinjections of thyrotropin-releasing hormone (TRH) were performed to determine potentially sensitive limbic brain sites to the ulcerogenic effect of TRH. Administration of TRH into the central nucleus of the amygdala (CEA) produced a high (80%) incidence of gastric lesions and also significantly stimulated acid secretion. Microinjections of TRH into other brain sites including superior colliculus, medial septum, substantia nigra and the hippocampus (CA1 area) were ineffective. Intra-CEA TRH-induced gastric lesions and acid secretion were prevented by vagotomy. These results indicate that the amygdala is of importance for mediating the ulcerogenic effect of brain TRH through peripheral vagal pathways.

摘要

利用促甲状腺激素释放激素（TRH）微量注射进行的研究，旨在确定对TRH致溃疡作用潜在敏感的边缘脑区。向杏仁核中央核（CEA）注射TRH会导致高比例（80%）的胃部损伤，并且显著刺激胃酸分泌。向包括上丘、内侧隔、黑质和海马体（CA1区）在内的其他脑区微量注射TRH则无效。切断迷走神经可预防CEA内TRH诱导的胃部损伤和胃酸分泌。这些结果表明，杏仁核对于通过外周迷走神经通路介导脑TRH的致溃疡作用至关重要。