发展能教给我们关于更年期的什么？
What can development teach us about menopause?
机构信息
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Brain Res. 2011 Mar 16;1379:109-18. doi: 10.1016/j.brainres.2010.11.094. Epub 2010 Dec 4.
Abstract
Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by a sensitive period of hormone responsiveness, and in both cases, the neurotransmitters GABA and glutamate, as well as synaptogenesis and cell proliferation are major hormone targets. This review compares and contrasts the effects of estradiol on the developing and aging brain and highlights new avenues of exploration and therapeutic development.
摘要
发展和衰老通常是镜像过程，这在雌激素的作用中可能也是如此，雌激素是一种调节大脑发育的强效内源性类固醇，也是一种用于缓解围绝经期负面成分的治疗药物。发育中的大脑和围绝经期的大脑都有一个对激素敏感的时期，在这两种情况下，神经递质 GABA 和谷氨酸，以及突触发生和细胞增殖都是主要的激素靶点。本文比较和对比了雌激素对发育中和衰老大脑的影响，并强调了新的探索和治疗发展途径。
相似文献
1
What can development teach us about menopause?发展能教给我们关于更年期的什么？
Brain Res. 2011 Mar 16;1379:109-18. doi: 10.1016/j.brainres.2010.11.094. Epub 2010 Dec 4.
2
The 'menopause' and the aging brain: causes and repercussions of hypoestrogenicity.“更年期”与大脑衰老：雌激素缺乏的原因及影响
Biogerontology. 2001;2(2):113-5. doi: 10.1023/a:1011537201380.
3
Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?一生中雌激素暴露的轨迹和表型：这与金发姑娘原则有什么关系？
Horm Behav. 2015 Aug;74:86-104. doi: 10.1016/j.yhbeh.2015.06.009. Epub 2015 Jun 27.
4
The two faces of estradiol: effects on the developing brain.雌二醇的两面性：对发育中大脑的影响。
Neuroscientist. 2009 Dec;15(6):599-610. doi: 10.1177/1073858409340924.
5
Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause.生殖衰老、围绝经期和绝经与认知变化。
Obstet Gynecol Clin North Am. 2018 Dec;45(4):751-763. doi: 10.1016/j.ogc.2018.07.011. Epub 2018 Oct 25.
6
Neuroendocrinology of female aging.女性衰老的神经内分泌学
Gend Med. 2005 Mar;2(1):41-56. doi: 10.1016/s1550-8579(05)80008-7.
7
Estrogen, synaptic plasticity and hypothalamic reproductive aging.雌激素、突触可塑性与下丘脑生殖衰老
Exp Gerontol. 2003 Jan-Feb;38(1-2):53-9. doi: 10.1016/s0531-5565(02)00183-3.
8
Menopause medicine: exercise and weight gain.更年期医学：运动与体重增加
Geriatrics. 2009 Jun;64(6):28-9.
9
Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders.可能存在下丘脑-垂体-海马（HPH）轴：海马特定神经雌二醇合成与衰老大脑神经发生之间的互惠关系，特别参考绝经和神经认知障碍。
Neurochem Res. 2019 Aug;44(8):1781-1795. doi: 10.1007/s11064-019-02833-1. Epub 2019 Jun 28.
10
Effect of Sex Hormones on Brain Connectivity Related to Sexual Function in Perimenopausal Women: A Resting-State fMRI Functional Connectivity Study.围绝经期女性性激素对与性功能相关的脑连接的影响：一项静息态 fMRI 功能连接研究。
J Sex Med. 2019 May;16(5):711-720. doi: 10.1016/j.jsxm.2019.03.004. Epub 2019 Apr 5.
引用本文的文献
1
Explaining Variation in Individual Aging, Its Sources, and Consequences: A Comprehensive Conceptual Model of Human Aging.解释个体衰老的变化、其来源和后果：人类衰老的综合概念模型。
Gerontology. 2023;69(12):1437-1447. doi: 10.1159/000534324. Epub 2023 Sep 28.
2
Behavioral, Oxidative, and Biochemical Effects of Omega-3 on an Ovariectomized Rat Model of Menopause.ω-3对去卵巢绝经大鼠模型的行为、氧化及生化影响
J Menopausal Med. 2021 Dec;27(3):132-140. doi: 10.6118/jmm.21016.
3
L. Regulates Glutathione Redox Stress and Normalizes Ggt1/Anpep Signaling to Alleviate OVX-Induced Kidney Dysfunction.L.调节谷胱甘肽氧化还原应激并使Ggt1/Anpep信号正常化以减轻去势诱导的肾功能障碍。
Front Pharmacol. 2021 Apr 26;12:628651. doi: 10.3389/fphar.2021.628651. eCollection 2021.
4
Metabotropic glutamate receptor subtype 5 (mGlu) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats.代谢型谷氨酸受体 5 型（mGlu）对于雌二醇减轻雌性大鼠光诱导的焦虑行为是必需的。
Physiol Behav. 2020 Feb 1;214:112770. doi: 10.1016/j.physbeh.2019.112770. Epub 2019 Dec 9.
5
Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?一生中雌激素暴露的轨迹和表型：这与金发姑娘原则有什么关系？
Horm Behav. 2015 Aug;74:86-104. doi: 10.1016/j.yhbeh.2015.06.009. Epub 2015 Jun 27.
6
Enhanced striatal β1-adrenergic receptor expression following hormone loss in adulthood is programmed by both early sexual differentiation and puberty: a study of humans and rats.成年后激素丧失增强纹状体β1-肾上腺素能受体表达是由早期性分化和青春期共同编程的：人类和大鼠的研究。
Endocrinology. 2013 May;154(5):1820-31. doi: 10.1210/en.2012-2131. Epub 2013 Mar 26.
7
Age and sex differences in the ventilatory response to hypoxia and hypercapnia in awake neonatal, pre-pubertal and young adult rats.在清醒的新生、青春期前和成年大鼠中，年龄和性别对低氧和高碳酸血症通气反应的影响。
Respir Physiol Neurobiol. 2012 Jan 15;180(1):79-87. doi: 10.1016/j.resp.2011.10.012. Epub 2011 Oct 29.
本文引用的文献
1
A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol.海马神经发生存在发育性性别差异，这种差异受内源性雌激素调节。
Biol Sex Differ. 2010 Nov 22;1(1):8. doi: 10.1186/2042-6410-1-8.
2
Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.通过含有 alpha7 亚基的烟碱型乙酰胆碱受体的内源性信号促进海马体中成年新生神经元的成熟和整合。
J Neurosci. 2010 Jun 30;30(26):8734-44. doi: 10.1523/JNEUROSCI.0931-10.2010.
3
Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury.脊髓损伤后慢性神经性疼痛发展过程中 NKCC1 和 KCC2 的作用。
Ann N Y Acad Sci. 2010 Jun;1198:168-72. doi: 10.1111/j.1749-6632.2010.05462.x.
4
GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems.GABA 能神经元对发育和成年神经发生过程中神经突生长和重塑的控制：不同系统的一般规律和差异。
Front Cell Neurosci. 2010 Apr 14;4:11. doi: 10.3389/fncel.2010.00011. eCollection 2010.
5
Estrogen's Place in the Family of Synaptic Modulators.雌激素在突触调节剂家族中的地位。
Mol Cell Pharmacol. 2009 Jan 1;1(5):258-262.
6
Does short-term estrogen therapy produce lasting benefits in brain?短期雌激素疗法会给大脑带来持久益处吗？
Endocrinology. 2010 Mar;151(3):843-5. doi: 10.1210/en.2009-1453.
7
Transient estradiol exposure during middle age in ovariectomized rats exerts lasting effects on cognitive function and the hippocampus.中年时期短暂的雌二醇暴露对去卵巢大鼠的认知功能和海马体具有持久的影响。
Endocrinology. 2010 Mar;151(3):1194-203. doi: 10.1210/en.2009-1245. Epub 2010 Jan 12.
8
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.细胞骨架的变化是雌激素对突触传递和可塑性产生急性影响的基础。
J Neurosci. 2009 Oct 14;29(41):12982-93. doi: 10.1523/JNEUROSCI.3059-09.2009.
9
Estrogen induces caspase-dependent cell death during hypothalamic development.雌激素在下丘脑发育过程中诱导依赖半胱天冬酶的细胞死亡。
J Neurosci. 2009 Aug 5;29(31):9714-8. doi: 10.1523/JNEUROSCI.0135-09.2009.
10
Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging.类固醇激素对成年雌性啮齿动物发情周期、怀孕、哺乳及衰老期间海马体神经发生的影响。
Front Neuroendocrinol. 2009 Aug;30(3):343-57. doi: 10.1016/j.yfrne.2009.03.007. Epub 2009 Apr 8.
Zotero 插件