三肽基肽酶 II 可作为受损蛋白酶体的替代物，以维持病毒在宿主细胞中的生长。
Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.
机构信息
James Hogg Research Center, Providence Heart+Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
出版信息
FEBS Lett. 2011 Jan 3;585(1):261-5. doi: 10.1016/j.febslet.2010.11.056. Epub 2010 Dec 8.
Abstract
The ubiquitin-proteasome system is known to be utilized by coxsackievirus to facilitate its propagation within the host cells. The present study explores the role of tripeptidyl peptidase II (TPPII), a serine peptidase contributing to protein turnover by acting downstream of the proteasome, in regulating coxsackievirus infection. Inhibition of TPPII does not affect virus replication in cells with functional proteasome. However, when the proteasome is impaired, TPPII appears to serve as an alternative to maintain low levels of virus infection. Our results suggest an important function of TPPII in the maintenance of viral growth and may have implications for anti-viral therapy.
摘要
已知泛素-蛋白酶体系统被柯萨奇病毒利用，以促进其在宿主细胞内的传播。本研究探讨了三肽基肽酶 II（TPPII）在调节柯萨奇病毒感染中的作用，TPPII 是一种丝氨酸肽酶，通过作用于蛋白酶体下游参与蛋白质周转。TPPII 的抑制作用并不影响具有功能蛋白酶体的细胞中的病毒复制。然而，当蛋白酶体受损时，TPPII 似乎作为一种替代物来维持低水平的病毒感染。我们的结果表明 TPPII 在维持病毒生长方面具有重要功能，这可能对抗病毒治疗具有重要意义。
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