Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.
Mol Cell Endocrinol. 2011 Feb 20;333(2):103-11. doi: 10.1016/j.mce.2010.11.032. Epub 2010 Dec 4.
Asthma is a common inflammatory disease for which the cause is not yet known. Studies of the epidemiology and natural history of childhood asthma into adulthood demonstrate a change in gender prevalence with age. Hormones and inflammation may interact in asthma pathogenesis and determine its course. The same may be true for some endocrine disorders, including diabetes and obesity. Obesity plays a major role in the development of the metabolic syndrome and has been identified as an important risk factor for chronic diseases such as type 2 diabetes mellitus. The prevalence of asthma has paralleled the rise in obesity, suggesting that shared environmental factors could affect both conditions. In addition, endocrine diseases and asthma may share common genetic determinants. In the first part of this review we assess endocrine influences on asthma and overlaps between endocrine disorders and asthma while in the second part we explore the potential benefit of comparative genetic analyses between asthma and endocrine diseases.
哮喘是一种常见的炎症性疾病，其病因尚不清楚。对儿童期哮喘向成年期发展的流行病学和自然史的研究表明，随着年龄的增长，性别患病率发生了变化。激素和炎症可能在哮喘发病机制中相互作用，并决定其病程。一些内分泌疾病也是如此，包括糖尿病和肥胖症。肥胖在代谢综合征的发展中起着重要作用，并已被确定为 2 型糖尿病等慢性疾病的重要危险因素。哮喘的患病率与肥胖症的上升平行，这表明共同的环境因素可能会影响这两种疾病。此外，内分泌疾病和哮喘可能有共同的遗传决定因素。在这篇综述的第一部分，我们评估了内分泌对哮喘的影响以及内分泌疾病与哮喘之间的重叠，而在第二部分，我们探讨了哮喘和内分泌疾病之间进行比较遗传分析的潜在益处。
