Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Semin Cell Dev Biol. 2011 Feb;22(1):77-81. doi: 10.1016/j.semcdb.2010.11.006. Epub 2010 Dec 4.
Bacterial infections are complex events. They are studied in a variety of simple model systems, using mammalian or non-mammalian hosts, all of which fail to reproduce fully the situation in infected patients. Each model presents a combination of conceptual, practical, and ethical advantages and disadvantages. In this review, we detail the use of Dictyostelium discoideum amoebae as a model to study Pseudomonas aeruginosa. More specifically, our aim is to explore what this additional model system can bring to our understanding of Pseudomonas infections. The study of interactions between Dictyostelium amoebae and Pseudomonas provides a view of the selection pressures exerted by environmental predators on Pseudomonas. It also represents a unique system to assess the virulence of very large numbers of Pseudomonas strains.
细菌感染是复杂的事件。它们在各种简单的模型系统中进行研究，使用哺乳动物或非哺乳动物宿主，但所有这些系统都不能完全再现感染患者的情况。每种模型都具有概念上、实践上和伦理上的优缺点。在这篇综述中，我们详细介绍了使用盘基网柄菌变形虫作为模型来研究铜绿假单胞菌。更具体地说，我们的目的是探讨这个额外的模型系统能给我们对铜绿假单胞菌感染的理解带来什么。研究盘基网柄菌变形虫与铜绿假单胞菌之间的相互作用，可以了解环境捕食者对铜绿假单胞菌施加的选择压力。它还代表了一个独特的系统，可以评估大量铜绿假单胞菌菌株的毒力。
