Cockle S M
Dept. of Biochemistry and Physiology, University of Reading, Whiteknights, UK.
FEBS Lett. 1990 May 21;264(2):253-6. doi: 10.1016/0014-5793(90)80261-g.
High concentrations of thyrotrophin-releasing hormone (TRH) are known to be present in the olfactory lobe, and the processing of the TRH prohormone in this region of the brain has been examined in this study. TRH-extended peptides have been detected in the rat olfactory lobe: these peptides accounted for approximately 11% of the total TRH immunoreactivity present in the tissue and contained the sequence pGlu-His-Pro-Gly-Arg exclusively at their N-termini. Extended peptides containing pGlu-His-Pro-Gly-Lys at their N-termini were not detected suggesting that incomplete cleavage occurs only at Arg-Arg residues in the TRH-prohormone. In view of the highly specific processing of the prohormone, it is likely that the TRH-extended peptides play important physiological roles.
已知在嗅叶中存在高浓度的促甲状腺激素释放激素（TRH），并且本研究已对该脑区中TRH前激素的加工过程进行了检测。在大鼠嗅叶中已检测到TRH延伸肽：这些肽约占组织中总TRH免疫反应性的11%，并且仅在其N端含有序列pGlu-His-Pro-Gly-Arg。未检测到在其N端含有pGlu-His-Pro-Gly-Lys的延伸肽，这表明不完全切割仅发生在TRH前激素的Arg-Arg残基处。鉴于前激素的高度特异性加工过程，TRH延伸肽很可能发挥重要的生理作用。
