可触及乳腺病变细针穿刺细胞学检查的快速染色及即时判读：诊断准确性、与乳腺X线摄影、超声检查及组织病理学的相关性

Rapid staining and immediate interpretation of fine-needle aspiration cytology for palpable breast lesions: diagnostic accuracy, mammographic, ultrasonographic and histopathologic correlations.

作者信息

Liew Phui-Ly, Liu Tse-Jia, Hsieh Mao-Chih, Lin Hsiu-Pen, Lu Ching-Fang, Yao Min-Szu, Chen Chi-Long

机构信息

Department of Pathology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ROC.

出版信息

Acta Cytol. 2011;55(1):30-7. doi: 10.1159/000320869. Epub 2010 Nov 26.

DOI:10.1159/000320869

PMID:21135519

Abstract

OBJECTIVE

We investigated the role and turn around time of rapid staining and immediate interpretation of fine-needle aspiration cytology (FNAC) for women with palpable breast lesions.

STUDY DESIGN

A total of 408 FNAC specimens from 400 patients with palpable breast lesions was analyzed for immediate interpretation and preliminary cytologic diagnosis. All cytological diagnoses were correlated with subsequent alcohol-fixed Papanicolaou-stained slides, mammographic, ultrasonographic and histopathological findings.

RESULTS

Of the 408 specimens, 243 (59.6%) were interpreted as benign, 37 (9.0%) atypical, 22 (5.4%) suspicious, 68 (16.7%) malignant, and 38 (9.3%) unsatisfactory. 132 of 408 (32.4%) had subsequent surgical procedures; the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 88.5, 100, 100, 81.9 and 92.4%, respectively. The average turn around time was 8.6 min. Mammographic results were available in 242 (59.3%) cases, with 112 (46.3%) undergoing surgical excision. In correlation with mammography and surgical pathology, the false-positive rate, false-negative rate, sensitivity, specificity and accuracy were 1.9, 10.5, 98.1, 89.5 and 95.8%, respectively.

CONCLUSIONS

Rapid FNAC interpretation is a useful, effective diagnostic method for palpable breast lesions in our healthcare environment.

摘要

目的

我们调查了快速染色及即时判读细针穿刺细胞学检查（FNAC）在有可触及乳腺病变女性中的作用及周转时间。

研究设计

对400例有可触及乳腺病变患者的408份FNAC标本进行即时判读及初步细胞学诊断分析。所有细胞学诊断均与后续酒精固定巴氏染色玻片、乳腺X线摄影、超声检查及组织病理学结果相关。

结果

408份标本中，243份（59.6%）判为良性，37份（9.0%）非典型，22份（5.4%）可疑，68份（16.7%）恶性，38份（9.3%）不满意。408份中有132份（32.4%）接受了后续手术；敏感性、特异性、阳性预测值、阴性预测值及准确性分别为88.5%、100%、100%、81.9%及92.4%。平均周转时间为8.6分钟。242例（59.3%）有乳腺X线摄影结果，其中112例（46.3%）接受了手术切除。与乳腺X线摄影及手术病理结果相关，假阳性率、假阴性率、敏感性、特异性及准确性分别为1.9%、10.5%、98.1%、89.5%及95.8%。