Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands.
Horm Res Paediatr. 2011;75(4):252-7. doi: 10.1159/000322257. Epub 2010 Dec 6.
Preterm infants are at risk of developing insulin resistance. It is not known whether insulin resistance in adult life is different between those with a low weight at term (preterm growth restraint, PGR) and those with a normal weight at term.
Insulin sensitivity, measured by the hyperinsulinemic euglycemic clamp, was investigated in 21-year-old adults born very preterm (i.e. <32 gestational weeks), of whom 17 were small for gestational age (SGA), 12 were appropriate for gestational age with PGR (AGA-PGR) and 28 were AGA-non-PGR.
Insulin sensitivity expressed as M value (glucose disposal mg/kg/min) was lower in AGA-non-PGR (8.9) than in SGA (11.0) or AGA-PGR subjects (10.4). These differences disappeared after adjustment for current body size. Linear growth between 3 months and 21 years of age was different between AGA-non-PGR and SGA subjects and between AGA-nonPGR subjects and the combined AGA-PGR and SGA subjects.
In young adults born very preterm, differences in insulin sensitivity between those born SGA, with PGR and without PGR are related to the current body composition.
早产儿存在发生胰岛素抵抗的风险。目前尚不清楚在足月时体重较轻（早产儿生长受限，PGR）和体重正常的婴儿中，其成年后的胰岛素抵抗是否存在差异。
本研究调查了 21 岁时极低出生体重（<32 周妊娠）的成年人的胰岛素敏感性，其中 17 名是小于胎龄儿（SGA），12 名是 PGR 合适胎龄儿（AGA-PGR），28 名是 AGA 非 PGR。
以 M 值（葡萄糖处置量 mg/kg/min）表示的胰岛素敏感性在 AGA-non-PGR（8.9）中低于 SGA（11.0）或 AGA-PGR 组（10.4）。这些差异在调整当前身体大小后消失。AGA-non-PGR 与 SGA 组之间以及 AGA-non-PGR 组与 AGA-PGR 和 SGA 组之间的线性生长在 3 个月至 21 岁之间存在差异。
在极低出生体重的年轻成年人中，出生时 SGA、PGR 和非 PGR 之间胰岛素敏感性的差异与当前的身体成分有关。
