Turin Elizabeth, Grados Marco A, Tierney Elaine, Ferenc Lisa M, Zabel Andrew, Comi Anne M
Kennedy Krieger Institute, Department of Psychiatry, Baltimore, MD 21205, USA.
J Nerv Ment Dis. 2010 Dec;198(12):905-13. doi: 10.1097/NMD.0b013e3181fe75ee.
Sturge-Weber syndrome (SWS) is characterized by seizures, port-wine birthmarks, vascular malformations, and rarely studied psychobehavioral features. This study describes a small group of outpatients (N = 16, age, 3-34 years) with Sturge-Weber syndrome seeking medical services (due to seizures, ophthalmological, and dermatological problems among others). The patients were screened for psychiatric diagnoses. The most frequent diagnoses were mood disorder (31%), disruptive behavior disorder (25%), and adjustment disorder (25%). A substance-related disorder was the most frequent in adults (67%). A significant association was found between disruptive behavior disorder not otherwise specified and more left frontal and left parietal involvement. A trend toward significant association of having a seizure in the past 3 months with disruptive behavior disorder not otherwise specified was observed. Problems with mood, attention, sleep, learning, and substance use were common. Disruptive behavior disorders and their association with medical conditions should be further investigated.
斯特奇-韦伯综合征（SWS）的特征包括癫痫发作、葡萄酒色斑、血管畸形以及很少被研究的心理行为特征。本研究描述了一小群患有斯特奇-韦伯综合征的门诊患者（N = 16，年龄3至34岁），他们因癫痫发作、眼科和皮肤科问题等前来寻求医疗服务。对这些患者进行了精神疾病诊断筛查。最常见的诊断是情绪障碍（31%）、破坏性行为障碍（25%）和适应障碍（25%）。物质相关障碍在成年人中最为常见（67%）。发现未另行指定的破坏性行为障碍与更多左侧额叶和左侧顶叶受累之间存在显著关联。观察到在过去3个月内有癫痫发作与未另行指定的破坏性行为障碍之间有显著关联的趋势。情绪、注意力、睡眠、学习和物质使用方面的问题很常见。破坏性行为障碍及其与医疗状况的关联应进一步研究。
