环孢菌素A诱导胸腺内克隆清除干扰的体外模型。
An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.
作者信息
Kosaka H, Matsubara H, Sogoh S, Ogata M, Hamaoka T, Fujiwara H
机构信息
Biomedical Research Center, Osaka University Medical School, Japan.
出版信息
J Exp Med. 1990 Jul 1;172(1):395-8. doi: 10.1084/jem.172.1.395.
The effects of cyclosporin A (CsA) on influencing the intrathymic clonal deletion were investigated by using our established thymic stromal cell clone with capacities to express Ia antigens and to produce a unique T cell growth factor. The following were revealed: (a) T cell clone with a given specificity was killed on the Ia+ stromal cell monolayer in the presence of the relevant antigens, a process depending on T cell receptor (TCR) stimulation; and (b) CsA allowed the T cell clone to continuously proliferate even during TCR stimulation by virtue of the stromal cell-derived T cell growth factor. This paper describes an in vitro model of a mechanism by which CsA is responsible for the generation of normally "forbidden" T cell clones.
利用我们建立的具有表达Ia抗原和产生独特T细胞生长因子能力的胸腺基质细胞克隆，研究了环孢素A（CsA）对影响胸腺内克隆清除的作用。结果如下：（a）具有特定特异性的T细胞克隆在相关抗原存在的情况下，在Ia +基质细胞单层上被杀死；这一过程依赖于T细胞受体（TCR）刺激；（b）由于基质细胞衍生的T细胞生长因子，即使在TCR刺激期间，CsA也能使T细胞克隆持续增殖。本文描述了一种体外模型机制，通过该机制CsA导致了正常情况下“被禁止”的T细胞克隆的产生。
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