Sierralta J, Gysling K
Department of Cell and Molecular Biology, Catholic University, Santiago, Chile.
Neurosci Lett. 1990 May 4;112(2-3):313-7. doi: 10.1016/0304-3940(90)90222-u.
The effect of a lack of dopamine (DA) in the striatum upon the K(+)-evoked release of cholecystokinin (CCK) from superfused rat striatal slices has been studied. Two pharmacological tools were used to deplete the nigrostriatal DA system: administration of alpha-methyl-p-tyrosine which competitively inhibits DA synthesis and lesions with 6-hydroxydopamine of the medial forebrain bundle. In both cases there was a significant inhibition of the K(+)-evoked release of CCK. The observed effects might be relevant on pathological conditions implying depletion of the DA system.
