Department of Paediatrics IV—Neonatology, Neuropaediatrics and Metabolic Diseases, Innsbruck Medical University, Innsbruck, Austria.
Arch Dis Child Fetal Neonatal Ed. 2011 Jul;96(4):F296-7. doi: 10.1136/adc.2010.192021. Epub 2010 Dec 7.
Congenital varicella syndrome (CVS) is a rare but deleterious consequence of primary varicella zoster virus (VZV) infection during pregnancy. Typical CVS stigmata are cerebral abnormalities, eye diseases and segmentally distributed, cicatricial skin lesions. In this paper the authors report on a male preterm infant, born at 30 weeks of gestation, who developed pustular skin lesions at the age of 4 weeks. The mother had suffered from chickenpox at 14 weeks of gestation. Apart from skin manifestations, critical bronchopulmonary dysplasia made the infant conspicuous. The VZV genome was detected in blood, respiratory secretions and skin lesions. At age 10 weeks he presented with extensive intestinal wall perforation, considered to be related to CVS, which finally led to death. This case shows for the first time the clinical course of CVS in a preterm infant. It illustrates the need for discussion of comprehensive VZV vaccination for seronegative women of childbearing age.
先天性水痘综合征（CVS）是孕妇原发性水痘带状疱疹病毒（VZV）感染的一种罕见但有害的后果。典型的 CVS 特征是脑异常、眼病和节段性分布的瘢痕性皮肤损伤。本文作者报告了一例男性早产儿，胎龄 30 周，出生后 4 周出现脓疱性皮肤损伤。母亲在妊娠 14 周时患水痘。除了皮肤表现外，严重的支气管肺发育不良使婴儿引人注目。在血液、呼吸道分泌物和皮肤损伤中检测到 VZV 基因组。在 10 周大时，他出现广泛的肠壁穿孔，被认为与 CVS 有关，最终导致死亡。本病例首次展示了 CVS 在早产儿中的临床过程。它说明了需要讨论对生育年龄的血清阴性妇女进行全面的 VZV 疫苗接种。
