Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan.
Circ J. 2011;75(1):201-3. doi: 10.1253/circj.cj-10-0842. Epub 2010 Dec 2.
Bucolome, a nonsteroidal antiinflammatory drug, enhances the effects of warfarin. In the present study, the effects of combination therapy (bucolome+warfarin) vs. warfarin alone on atrial fibrillation were investigated.
Combined therapy resulted in a decrease in the warfarin dose to approximately one-third. The fluctuations of the international normalized ratio and the time in therapeutic range were similar in both groups. There was no adverse effect in either group. Interestingly, uric acid was lower in the bucolome group.
Bucolome enhanced the effects of warfarin, resulting in a decreased dose of warfarin without adverse effects and it showed similar anticoagulant stability to warfarin alone.
布可隆（一种非甾体类抗炎药）可增强华法林的效果。本研究旨在探讨布可隆联合华法林治疗与华法林单药治疗相比，对房颤的疗效。
联合治疗可使华法林剂量减少至约三分之一。两组的国际标准化比值波动和治疗范围内时间相似。两组均无不良反应。有趣的是，布可隆组的尿酸水平较低。
布可隆增强了华法林的效果，使华法林的剂量降低而无不良反应，且抗凝稳定性与华法林单药治疗相似。
