硫胺素对铅在组织中分布的影响。

The effects of thiamin on the tissue distribution of lead.

作者信息

Kim J S, Blakley B R, Rousseaux C G

机构信息

Department of Veterinary Physiological Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.

出版信息

J Appl Toxicol. 1990 Apr;10(2):93-7. doi: 10.1002/jat.2550100206.

DOI:10.1002/jat.2550100206

PMID:2113935

Abstract

The effects of thiamin on the tissue distribution of lead were evaluated in Sprague-Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg-1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg-1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P less than 0.0001), liver (P less than 0.0001) and kidney (P less than 0.0001) concentrations of lead. Thiamin (50 mg kg-1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg-1 body weight). The combined treatment was more effective than the respective individual treatments.

摘要

在饮用含1000 ppm醋酸铅的水的Sprague-Dawley大鼠中评估硫胺素对铅组织分布的影响，这些大鼠每天接受硫胺素（25或50 mg kg-1体重，腹腔注射）、乙二胺四乙酸钙（50 mg kg-1体重，腹腔注射）或它们的组合治疗8周。亚毒性剂量的铅在治疗期间未改变体重增加、饲料和水的消耗量。硫胺素降低了血液（P<0.0001）、肝脏（P<0.0001）和肾脏（P<0.0001）中的铅浓度。硫胺素（50 mg kg-1体重）比硫胺素（25 mg kg-1体重）更有效地降低了组织中的铅浓度。联合治疗比各自单独治疗更有效。