Nakamura Hiroyuki
Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan.
Yakugaku Zasshi. 2010 Dec;130(12):1687-94. doi: 10.1248/yakushi.130.1687.
The cell-killing effect of boron neutron capture therapy (BNCT) is due to the nuclear reaction of two essentially nontoxic species, boron-10 ((10)B) and thermal neutrons, whose destructive effect is well observed in boron-loaded tissues. High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve efficient neutron capture therapy of cancers. This review focuses on liposomal boron delivery system (BDS) as a recent promising approach that meet these requirements for BNCT. BDS involves two strategies: (1) encapsulation of boron in the aqueous core of liposomes and (2) accumulation of boron in the liposomal bilayer. In this review, recent development of liposomal boron delivery system is summarized.
硼中子俘获疗法（BNCT）的细胞杀伤作用源于两种基本无毒的物质——硼-10（¹⁰B）和热中子的核反应，其破坏作用在含硼组织中得到了充分观察。硼在肿瘤组织中的高积累和选择性递送是实现高效癌症中子俘获疗法的最重要要求。本综述重点关注脂质体硼递送系统（BDS），这是一种满足BNCT这些要求的近期有前景的方法。BDS涉及两种策略：（1）将硼包裹在脂质体的水相核心中，以及（2）使硼在脂质体双层中积累。在本综述中，总结了脂质体硼递送系统的最新进展。
