Murata Yoshifumi, Isobe Takashi, Kofuji Kyoko, Maida Chieko, Miyamoto Etsuko
Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan.
Yakugaku Zasshi. 2010 Dec;130(12):1755-9. doi: 10.1248/yakushi.130.1755.
Film dosage forms containing metronidazole (MZ) were prepared from natural polysaccharides, such as pullulan (PUL) or sodium alginate (ALG), without heating or controlling the pH. The release profiles of MZ from the films were investigated. In the absence of a drug, the casting method resulted in the polysaccharide forming a circular film, and the presence of MZ affected film formation. The thickness of the film was controllable by adjusting the concentration of ALG, and regular unevenness was observed on the surface of film. The film prepared with PUL or ALG readily swelled in dissolution medium, and released MZ with disintegration. The films prepared from the polysaccharides could be promising candidates as dosage forms containing MZ, and would be expected to show drug dissolution in the surface of skin.
含有甲硝唑（MZ）的薄膜剂型由天然多糖如支链淀粉（PUL）或海藻酸钠（ALG）制备而成，无需加热或控制pH值。研究了MZ从薄膜中的释放曲线。在没有药物的情况下，流延法导致多糖形成圆形薄膜，而MZ的存在会影响薄膜的形成。薄膜的厚度可通过调节ALG的浓度来控制，并且在薄膜表面观察到规则的不均匀性。用PUL或ALG制备的薄膜在溶解介质中容易膨胀，并随着崩解释放出MZ。由多糖制备的薄膜有望成为含MZ的剂型，并有望在皮肤表面实现药物溶解。
