Filous Ales, Osmera Jakub, Hlozanek Martin, Mahelkova Gabriela
Department of Ophthalmology for Children and Adults, Charles University, 2nd Faculty of Medicine, Prague, Czech Republic.
Eur J Ophthalmol. 2011 Jul-Aug;21(4):374-8. doi: 10.5301/EJO.2010.6090.
To determine the central corneal thickness (CCT) in microphthalmic aphakic or pseudophakic eyes as well as in microphthalmic eyes without any history of eye surgery.
Thirty-two patients with a mean age of 6.41±5.24 years after congenital cataract surgery with absolute microcornea, i.e., horizontal corneal diameter (HCD)<10 mm, or relative microcornea, i.e., HCD 10-11 mm but in the affected eye at least 0.5 mm smaller compared to the fellow eye, formed group A. Thirteen patients of mean age 0.94±1.22 years with absolute or relative microcornea plus another developmental anomaly of an eye without any history of eye surgery formed group B. The patients with corneal edema or scars were excluded. The control group consisted of 124 healthy school-aged children. Horizontal corneal diameter was measured with caliper and CCT with an ultrasound pachymeter. In infants, these measurements were performed under general anesthesia.
In 48 eyes in group A and in 16 eyes in group B, the mean CCT was 635.13±65.35 µm and 642.31±93.07 µm, respectively, which was significantly greater (p<0.0001 and p=0.0018) in comparison with the mean CCT (553.58±33.12 µm) in the control group. Regression curve demonstrated the significant increase of CCT values along with the decrease of HCD in microphthalmic eyes.
Small corneas in microphthalmic eyes either with or without congenital cataract surgery have significantly higher CCT. The results demonstrate significant negative correlation between horizontal corneal diameter and CCT.
确定小眼球无晶状体或人工晶状体眼以及无任何眼部手术史的小眼球的中央角膜厚度（CCT）。
32例先天性白内障手术后平均年龄为6.41±5.24岁的患者，患有绝对小角膜，即水平角膜直径（HCD）<10mm，或相对小角膜，即HCD为10 - 11mm，但患眼比健眼至少小0.5mm，组成A组。13例平均年龄为0.94±1.22岁的患者，患有绝对或相对小角膜以及另一种眼部发育异常且无任何眼部手术史，组成B组。排除有角膜水肿或瘢痕的患者。对照组由124名健康学龄儿童组成。用卡尺测量水平角膜直径，用超声角膜测厚仪测量CCT。对于婴儿，这些测量在全身麻醉下进行。
A组48只眼和B组16只眼中，平均CCT分别为635.13±65.35μm和642.31±93.07μm，与对照组的平均CCT（553.58±33.12μm）相比显著更高（p<0.0001和p = 0.0018）。回归曲线显示小眼球中CCT值随HCD减小而显著增加。
无论有无先天性白内障手术，小眼球中的小角膜CCT均显著更高。结果表明水平角膜直径与CCT之间存在显著负相关。
