Department of Microbiology, Kanazawa Medical University School of Medicine, Uchinada, Ishikawa, Japan.
Microbiol Immunol. 2010 Oct;54(10):639-43. doi: 10.1111/j.1348-0421.2010.00260.x.
Theiler’s murine encephalomyelitis virus is divided into two subgroups, TO and GDVII, inducing subgroup-specific diseases. In order to investigate the role(s) of nonstructural proteins of TMEV, L and L(∗), leaders of two subgroups, were separately expressed with or without L(∗) in BHK-21 cells. Expression of L increased the number of apoptotic cells. L(∗)/BHK-21 cells constitutively expressing L(∗) showed the decrease in cell death induced by L. These results suggest that L and L(∗) regulate apoptosis during viral infection and contribute to TMEV subgroup-specific biological activities.
西勒氏鼠脑脊髓炎病毒分为两个亚群，TO 和 GDVII，可引起亚群特异性疾病。为了研究 TMEV 的非结构蛋白的作用，L 和 L(∗)，两个亚群的领导者，分别在 BHK-21 细胞中表达，有无 L(∗)。L 的表达增加了凋亡细胞的数量。持续表达 L(∗)的 L(∗)/BHK-21 细胞显示出 L 诱导的细胞死亡减少。这些结果表明，L 和 L(∗)在病毒感染过程中调节细胞凋亡，并有助于 TMEV 亚群特异性的生物学活性。
