[The relationship between the lung function and the level of TNF-α in serum in COPD department of respiratory].

AIM

To explore the relationship between the lung function and the level of TNF-α in serum in COPD.

METHODS

60 patients with COPD and 35 normal subjects were involved in the study. The serum TNF-α level was measured by ELISA and the lung function were determined.

RESULTS

The level of TNF-α were significantly different in acute and stable COPD group, control group (P < 0.01). The levels of FEVI, FVC, FEVI/FVC and MMEF in acute and stable COPD group were significantly lower than those control group (P < 0.01). The levels of TNF-α was negatively correlated with FEVI, FVC, FEVI/FVC and MMEF (r = -0.586, -0.714, -0.527, -0.639, P < 0.05).

CONCLUSION

The TNF-α are involved in airway inflammation and the pathogenetic process of COPD, and may influence the lung function.