Gautam P, Shrestha J K, Joshi S N
Lumbini Eye Institute, BP Koirala Lion's Center for Ophthalmic Studies, Bhairahawa Rupandehi Nepal.
Nepal J Ophthalmol. 2009 Jul-Dec;1(2):114-7. doi: 10.3126/nepjoph.v1i2.3685.
age-related macular degeneration (ARMD) is a leading cause of blindness in the elderly population.
to frame a profile of patients withARMD and find out the factors associated with it
a cross-sectional study was carried out including a total of 75 patients with ARMD presenting to the out-patient department of a tertiary level ophthalmic center in Kathmandu. The data pertaining to their demography, ocular and systemic history and the findings of clinical examination and laboratory investigations were analyzed. The quality of life was assessed based on their dependability on the others for daily activity.
mean age of presentation of ARMD was 73 years +/- 7.93. Of the total, 44 were male and 31 female. Smoking was significantly associated with ARMD (p<0.01). 47 of the subjects had a sedentary lifestyle and 28 a non-sedentary lifestyle. Sedentary life style was significantly associated with ARMD (p=0.028). 48 subjects were hypertensive. Systemic hypertension was significantly associated with ARMD (p = 0.015). 45 had dry ARMD, 21 had wet ARMD and 9 ofthemhad a mixed variety. Thirteen out of the 75 study subjects were leading a normal life while 45 of them had some limitation (self-care only) and 17 of them were dependent on the others for their daily activity. The quality of life was not significantly different between dry and wet ARMD (p = 0.40).
sedentary life style, smoking and hypertension are the modifiable factors that are associated with ARMD. A significant number of people with the ARMD have a compromised quality of life.
年龄相关性黄斑变性（ARMD）是老年人群失明的主要原因。
勾勒出ARMD患者的概况，并找出与之相关的因素。
进行了一项横断面研究，共纳入75例在加德满都一家三级眼科中心门诊就诊的ARMD患者。分析了他们的人口统计学、眼部和全身病史以及临床检查和实验室检查结果。根据他们在日常活动中对他人的依赖程度评估生活质量。
ARMD患者的平均就诊年龄为73岁±7.93岁。其中，男性44例，女性31例。吸烟与ARMD显著相关（p<0.01）。47名受试者有久坐不动的生活方式，28名有非久坐不动的生活方式。久坐不动的生活方式与ARMD显著相关（p=0.028）。48名受试者患有高血压。全身性高血压与ARMD显著相关（p = 0.015）。45例为干性ARMD，21例为湿性ARMD，其中9例为混合性。75名研究对象中有13人生活正常，45人有一定限制（仅能自理），17人在日常活动中依赖他人。干性和湿性ARMD患者的生活质量无显著差异（p = 0.40）。
久坐不动的生活方式、吸烟和高血压是与ARMD相关的可改变因素。相当数量的ARMD患者生活质量受损。
