[微生物生产1,3-二羟基丙酮的代谢工程研究进展]
[Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone].
作者信息
Sun Lihui, Hu Zhongce, Zheng Yuguo, Shen Yinchu
机构信息
Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
出版信息
Sheng Wu Gong Cheng Xue Bao. 2010 Sep;26(9):1218-24.
1,3-Dihydroxyacetone is widely used in cosmetics, medicines and food products. We reviewed the recent progress in metabolic pathways, key enzymes, as well as metabolic engineering for microbial production of 1,3-dihydroxyacetone. We addressed the research trend to increase yield of 1,3-dihydroxyacetone by improving the activity of glycerol dehydrogenase with genetic engineering, and regulating of fermentation process based on metabolic characteristic of the strain.
1,3 - 二羟基丙酮广泛应用于化妆品、药品和食品中。我们综述了微生物生产1,3 - 二羟基丙酮的代谢途径、关键酶以及代谢工程方面的最新进展。我们探讨了通过基因工程提高甘油脱氢酶活性以及基于菌株代谢特性调控发酵过程来提高1,3 - 二羟基丙酮产量的研究趋势。
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