Cooper J A
Fred Hutchinson Cancer Research Center, Seattle, Washington.
Curr Opin Cell Biol. 1990 Apr;2(2):285-95. doi: 10.1016/0955-0674(90)90021-6.
The study of oncogenes offers insights into many steps in signal transduction. Rapid progress is possible because of the combination of biochemistry and genetics--unique in vertebrate cell biology--the availability of specific clones and antibodies, sequence information, dominant mutants, and biochemical assays of function. The wealth of detail on oncogenes and proto-oncogenes continues to increase dramatically. Hopefully, in the next year or two some of the gaps will be filled in and all the steps along at least one pathway from the cell membrane to the nucleus will be understood.
对癌基因的研究为信号转导的多个步骤提供了深入见解。由于生物化学与遗传学的结合（这在脊椎动物细胞生物学中是独一无二的）、特定克隆和抗体的可获得性、序列信息、显性突变体以及功能的生化分析，快速进展成为可能。关于癌基因和原癌基因的详细信息数量仍在急剧增加。有望在未来一两年内填补一些空白，并至少理解从细胞膜到细胞核的一条途径上的所有步骤。
