Chen Na, Wu Ying-Liang, Wang Jin-Hui
State Key Lab for Brain and Cognitive Sciences, National Lab for Protein Sciences, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 Feb;24(1):14-7.
To investigate the intrinsic mechanisms underlying spike programming at pyramidal neurons and interneurons in layer II/III of sensorimotor cortex.
Electrical signals at the cortical neurons were recorded in current clamp model with multi-clamp700B Amplifiers. Signals were inputted into pClamp and Origin for data acquisition and analyses.
Compared to pyramidal neurons, interneurons express the higher capacity of spikes and the more stability of spike programming, which are mechanistically caused by lower threshold potentials and shorter refractory periods.
The refractory periods and threshold potentials directly influence the programming of sequential spikes.
研究感觉运动皮层II/III层锥体神经元和中间神经元动作电位编程的内在机制。
在电流钳模式下，使用多通道700B放大器记录皮层神经元的电信号。信号输入到pClamp和Origin软件中进行数据采集和分析。
与锥体神经元相比，中间神经元表现出更高的动作电位产生能力和更稳定的动作电位编程，其机制是较低的阈电位和较短的不应期。
不应期和阈电位直接影响连续动作电位的编程。
