Center for Bioinformatics, Colorado State University, Fort Collins, CO 80525, USA.
Ann Med. 2011 Feb;43(1):1-12. doi: 10.3109/07853890.2010.538078. Epub 2010 Dec 8.
Multiple microarray studies have documented the importance of circadian regulation of gene expression in different species under many experimental conditions. However, these reports often differ with respect to the identity and total number of oscillating genes. This review explores the interrelated questions of: How many genes are oscillating within individual tissues or systems? What are the forces that drive these oscillations? What are the methodological sources contributing to the discrepancy between estimates of gene oscillation? And finally, what are the physiological and systemic implications of oscillatory gene expression with respect to circadian molecular biology? Since this remains an evolving area of investigation, this hypothetical and speculative review also highlights the potential limitations faced by the current data in the literature relating to the novel paradigm(s) proposed.
多项微阵列研究记录了在许多实验条件下不同物种中基因表达的昼夜节律调节的重要性。然而，这些报告在振荡基因的数量和身份上往往存在差异。这篇综述探讨了以下相互关联的问题：在单个组织或系统中，有多少基因在振荡？是什么力量推动了这些振荡？有哪些方法学来源导致了对基因振荡的估计之间的差异？最后，振荡基因表达对生物钟分子生物学的生理和系统影响是什么？由于这仍然是一个不断发展的研究领域，因此，这篇假设性和推测性的综述也强调了当前文献中与所提出的新范式相关的数据所面临的潜在局限性。
