Stanewsky Ralf
Universität Regensburg, Institut für Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitätsstrasse 31, 93040 Regensburg, Germany.
J Neurobiol. 2003 Jan;54(1):111-47. doi: 10.1002/neu.10164.
The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks.
几十年来，果蝇一直是昼夜节律研究人员青睐的研究对象。行为、遗传和分子研究有助于揭示昼夜计时和节律行为的遗传基础。相反，直到最近，哺乳动物节律研究主要局限于描述性和生理学方法。与许多其他研究领域一样，这种小苍蝇与我们人类物种之间基本生物学原理的惊人相似性，推动了揭示哺乳动物生物钟机制遗传基础的研究进展。不仅基本机制，而且参与建立我们昼夜节律系统的分子，都再次取自或改编自果蝇。本综述将试图对这两个系统进行比较概述，突出昆虫和小鼠生物钟的相似性以及特殊性。
