Department of Community Medicine, University of Tromsø, Tromsø, Norway.
Eur J Neurol. 2011 May;18(5):737-43. doi: 10.1111/j.1468-1331.2010.03263.x. Epub 2010 Dec 8.
The role of cardiovascular risk factors in the pathogenesis of cognitive impairment and dementia remains still unclear. We examined the impact of cardiovascular risk factors on cognitive function in a large longitudinal population study.
Subjects were 5033 stroke-free men and women who participated in a longitudinal population-based study. Cardiovascular risk factors were measured at baseline, and cognitive function was assessed after 7 years of follow-up with verbal memory test, digit-symbol coding test, and tapping test.
Diabetes, systolic blood pressure, and current smoking were independently associated with lower cognitive test results in men and women. Low physical activity was independently associated with lower scores in women. We found no consistent association between total-cholesterol, HDL-cholesterol, coronary heart disease or BMI, and cognitive test results.
Diabetes, smoking, hypertension, and low physical activity were associated with lower cognitive test results. The study suggests that these modifiable risk factors should be emphasized in the prevention of cognitive decline.
心血管危险因素在认知障碍和痴呆发病机制中的作用仍不清楚。我们在一项大型纵向人群研究中检查了心血管危险因素对认知功能的影响。
受试者为 5033 名无卒中的男性和女性，他们参加了一项纵向基于人群的研究。在基线时测量心血管危险因素，在 7 年的随访后，通过言语记忆测试、数字符号编码测试和叩诊测试评估认知功能。
糖尿病、收缩压和当前吸烟与男性和女性的认知测试结果较低独立相关。低体力活动与女性的得分较低独立相关。我们没有发现总胆固醇、高密度脂蛋白胆固醇、冠心病或 BMI 与认知测试结果之间存在一致的关联。
糖尿病、吸烟、高血压和低体力活动与认知测试结果较低有关。该研究表明，这些可改变的危险因素在预防认知能力下降方面应得到重视。
