Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, MI, USA.
Equine Vet J. 2011 Jan;43(1):117-20. doi: 10.1111/j.2042-3306.2010.00158.x.
Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
磺胺增效剂组合的药物不良反应在许多物种中很常见，表现为胃肠道疾病、皮肤病理和血液学异常。在本病例系列中，描述了 4 匹马在正常剂量下使用磺胺增效剂组合治疗时和 1 匹驹接受超剂量治疗时出现的神经异常。这些马出现了高步态、兴奋和行为异常。一旦停止用药，所有症状均消退，且无马出现残留缺陷。未发现其他导致观察到的神经缺陷的原因。这些临床症状似乎代表了对一些常用抗菌组合药物的新型药物不良反应。
