Casellas J M, Goldberg M, Orellana N, Morosini M I, Negri M C, Arduino S
Department of Infectious Diseases and Microbiology, Universidad Católica, Buenos Aires, Argentina.
Infection. 1990 May-Jun;18(3):193-5. doi: 10.1007/BF01642115.
The in vitro activity of cefpirome was evaluated against strains that showed conflicting results for third generation cephalosporins. Against isolates with derepressed inducible chromosomal cephalosporinase (n = 40) cefpirome was the sole cephalosporin with an MIC90 in the susceptible range; Klebsiella spp. with plasmid-mediated beta-lactamases (broad spectrum SHV-2 or SHV-2 type) (n = 40) remained most susceptible to ceftizoxime and cefpirome; against aminoglycoside-resistant Pseudomonas aeruginosa (n = 50), cefpirome was as active as ceftazidime and cefoperazone; against oxacillin-susceptible and oxacillin-resistant Staphylococcus spp., (n = 40), cefpirome was more active than other third generation cephalosporins but killing was inadequate against both oxacillin-resistant staphylococci and enterococci.
对第三代头孢菌素呈现矛盾结果的菌株进行了头孢匹罗的体外活性评估。对于具有去阻遏诱导型染色体头孢菌素酶的分离株（n = 40），头孢匹罗是唯一MIC90处于敏感范围的头孢菌素；携带质粒介导的β-内酰胺酶（广谱SHV-2或SHV-2型）的克雷伯菌属（n = 40）对头孢唑肟和头孢匹罗仍最敏感；对于耐氨基糖苷类的铜绿假单胞菌（n = 50），头孢匹罗与头孢他啶和头孢哌酮活性相当；对于对苯唑西林敏感和耐药的葡萄球菌属（n = 40），头孢匹罗比其他第三代头孢菌素活性更强，但对耐苯唑西林葡萄球菌和肠球菌的杀菌效果不佳。
