Lian Zuping, Lu Yunxin, Hou Encun, Wang Xin
Guangxi TCM College Ruikang Hospital, Nanning, Guangxi 530011, P.R.China.
Zhongguo Fei Ai Za Zhi. 2006 Feb 20;9(1):74-7. doi: 10.3779/j.issn.1009-3419.2006.01.19.
Chemotherapy is a common way to treat advanced non-small cell lung cancer (NSCLC). The response rate of chemotherapy is only 20%-50%, and the side effects are serious. To improve efficacy and quality of life and to reduce side effects of chemotherapy become main tasks of clinical researches. The aim of this study is to evaluate GP regimen alone and GP regimen combined with Kanglaite on the efficacy, side effects and the improvement of quality of life in the treatment of advanced NSCLC.
Randomly fifty patients with NSCLC in stage III and IV were treated by GP regimen combining with Kanglaite, and fifty patients were treated with GP regimen alone. Kanglaite was used on the first day of each chemotherapy cycle for consecutive 10 days, and the dosage was 200ml/d. GP regimen included gemcitabine 1000mg/m² on 1st and 8th days and cisplatin 80mg/m² on 2nd day. The treatment was repeated every three weeks. The efficacy, side effect and quality of life were compared after two cycles of chemotherapy.
Response rate was 52% in combining group and 32% in control group. The rates were different between the two groups (Chi-square=4.04, P < 0.05). Quality of life in combining group was significantly higher than that in control group after treatment (t=2.8, P < 0.05). The incidence of side effects in combining group was lower than that in control group, and the degree was also slighter.
Kanglaite in combination with GP regimen can be used for the treatment of advanced NSCLC. It can improve efficacy and the quality of life, and reduce the side effect of chemotherapy.
化疗是治疗晚期非小细胞肺癌（NSCLC）的常用方法。化疗的有效率仅为20%-50%，且副作用严重。提高化疗疗效、改善生活质量以及减轻化疗副作用成为临床研究的主要任务。本研究旨在评估单纯GP方案以及GP方案联合康莱特治疗晚期NSCLC的疗效、副作用及生活质量改善情况。
将50例Ⅲ期和Ⅳ期NSCLC患者随机分为两组，一组采用GP方案联合康莱特治疗，另一组单纯采用GP方案治疗。在每个化疗周期的第1天开始使用康莱特，连续使用10天，剂量为200ml/d。GP方案包括第1天和第8天使用吉西他滨1000mg/m²，第2天使用顺铂80mg/m²。每三周重复一次治疗。化疗两个周期后比较两组的疗效、副作用及生活质量。
联合组有效率为52%，对照组为32%。两组有效率差异有统计学意义（χ²=4.04，P<0.05）。治疗后联合组生活质量明显高于对照组（t=2.8，P<0.05）。联合组副作用发生率低于对照组，且程度较轻。
康莱特联合GP方案可用于治疗晚期NSCLC。它能提高疗效和生活质量，并减轻化疗副作用。
