Zrour-Hassen Saoussen, Jguirim Mahbouba, Aouam Karim, Korbaa Wided, Younes Mohamed, Bejia Ismail, Touzi Mongi, Bergaoui Naceur
Service de Rhumatologie, CHU Fattouma Bourguiba de Monastir, Monastir, Tunisie.
Therapie. 2010 Sep-Oct;65(5):465-73. doi: 10.2515/therapie/2010061. Epub 2010 Dec 13.
The aim of this study is to determine the safety of commonly prescribed antirheumatic drugs at childbearing age, in pregnancy and lactation, through systematic literature review. Patients who take cytotoxic drugs should be informed of the risks of impared fertility. During pregnancy, non steroidal anti-inflammatory drugs (NSAIDs) can be safely administered until gestational week 32. Acetaminophen and low to moderate doses of corticosteroids are safe. Among, the disease-modifying agents, antimalarial agents, sulfasalazine, azathioprine and ciclosporin are compatible with pregnancy, and can be administered until birth. Paracetamol, prednison, antimalarial agents, sulfasalazine and most NSAIDs can safely be used by lactating mothers. To ensure a favourable outcome for both the mother and the child, the pregnancy should be planned, started during a period of disease stability, monitored closely and treated as needed.
本研究的目的是通过系统的文献综述，确定常用抗风湿药物在育龄期、孕期和哺乳期的安全性。服用细胞毒性药物的患者应被告知生育能力受损的风险。孕期可安全使用非甾体抗炎药（NSAIDs）至妊娠32周。对乙酰氨基酚和低至中等剂量的皮质类固醇是安全的。在改善病情的药物中，抗疟药、柳氮磺胺吡啶、硫唑嘌呤和环孢素与妊娠相容，可在分娩前使用。对乙酰氨基酚、泼尼松、抗疟药、柳氮磺胺吡啶和大多数NSAIDs可由哺乳期母亲安全使用。为确保母婴均有良好结局，应计划妊娠，在疾病稳定期开始妊娠，密切监测并根据需要进行治疗。
