Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, School of Medicine, University of Leeds, UK.
Injury. 2010 Nov;41 Suppl 2:S57-61. doi: 10.1016/S0020-1383(10)70011-5.
We evaluated the peripheral release of inflammatory mediators after femoral fracture and subsequent intramedullary reaming using the RIA reamers. IL-6 was elevated after trauma, and reaming with RIA induced a measurable second hit response. However, despite a higher ISS, the levels of IL-6 in the RIA group were similar to the levels measured in a group of patients where reaming of the femoral canal was performed using conventional reamers. There was one death related to fat embolism syndrome in the conventional reamers group. However, the overall incidence of complications was low and similar between the 2 groups of studied patients. In polytrauma patients, large scale studies are desirable to evaluate further the immuno-inflammatory response using the RIA reamers prior to the instrumentation of the femoral canal.
我们评估了使用 RIA 扩孔器后股骨骨折和随后髓内扩孔引起的外周炎症介质释放。创伤后白细胞介素 6 升高，RIA 扩孔引起可测量的二次打击反应。然而，尽管 ISS 较高，但 RIA 组的白细胞介素 6 水平与使用传统扩孔器进行股骨髓腔扩孔的患者组测量的水平相似。传统扩孔器组有 1 例与脂肪栓塞综合征相关的死亡病例。然而，两组研究患者的并发症总发生率较低且相似。在多发伤患者中，需要进行大规模研究，以使用 RIA 扩孔器在股骨髓腔器械置入前进一步评估免疫炎症反应。
