Pak G D, Sverchkova V S, Danilevskaia T N
Kosm Biol Aviakosm Med. 1990 Mar-Apr;24(2):4-9.
This paper presents an overview of investigations of blood coagulation of man exposed to hypoxic hypoxia or hypoxia combined with hypercapnia. Blood coagulation changes were related to the level of hypoxia and correlated with variations in blood gases and acid-base characteristics. Prognostic criteria associated with increased coagulation in response to hypoxia were formulated. It was found that hypoxia of any degree reduced significantly the stimulation effect of epinephrine on blood coagulation and fibrinolysis. The paper discusses the relationship between respiratory and hemostatic functions of blood and mechanisms regulating its aggregation during hypoxia of various degree. It is recommended to add carbon dioxide in moderate concentrations to the hypoxic environment in order to prevent blood hypercoagulation and to increase its resistance to acute hypoxia and epinephrine-induced lesions. It is concluded that the functional state of the blood coagulation system is controlled by the concentration and proportion of oxygen and carbon dioxide, i. e. biologically active gases, in inhaled air and blood.
本文概述了暴露于低氧性缺氧或缺氧合并高碳酸血症的人体血液凝固的研究情况。血液凝固变化与缺氧程度相关，并与血气及酸碱特性的变化相关。制定了与缺氧时凝血增加相关的预后标准。发现任何程度的缺氧都会显著降低肾上腺素对血液凝固和纤维蛋白溶解的刺激作用。本文讨论了血液呼吸和止血功能之间的关系以及在不同程度缺氧期间调节其聚集的机制。建议在低氧环境中添加适度浓度的二氧化碳，以防止血液高凝，并增加其对急性缺氧和肾上腺素诱导损伤的抵抗力。得出的结论是，血液凝固系统的功能状态受吸入空气和血液中氧气和二氧化碳（即生物活性气体）的浓度和比例控制。
