Ramirez G, Bercu B B, Bittle P A, Ayers C W, Ganguly A
Department of Internal Medicine, James A. Haley Veterans' Hospital, Tampa, FL 33612.
Metabolism. 1990 Jul;39(7):764-8. doi: 10.1016/0026-0495(90)90114-r.
Exogenous synthetic growth hormone-releasing hormone (GHRH [hpGRF-40]), 1 microgram/kg body weight, was administered intravenously (IV) to eight men with chronic renal failure on chronic hemodialysis and to seven men matched for age (control group). Basal and stimulated growth hormone (GH) concentrations following GHRH (hpGRF-40) in renal failure patients were significantly higher than in controls. Basal prolactin and somatomedin C/insulin-like growth factor-1 (SmC/IGF-1) concentrations were significantly higher in the renal failure patients compared with controls. Following GHRH there was no further increase in serum concentration of thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, SmC/IGF-1, or cortisol. GH appears to be the only pituitary hormone where there is an exaggerated response to its specific releasing hormone in adults with renal failure.
对8名接受慢性血液透析的慢性肾衰竭男性和7名年龄匹配的男性（对照组）静脉注射（IV）外源性合成生长激素释放激素（GHRH [hpGRF - 40]），剂量为1微克/千克体重。肾衰竭患者在注射GHRH（hpGRF - 40）后的基础和刺激生长激素（GH）浓度显著高于对照组。与对照组相比，肾衰竭患者的基础催乳素和生长调节素C/胰岛素样生长因子-1（SmC/IGF - 1）浓度显著更高。注射GHRH后，促甲状腺激素（TSH）、促卵泡激素（FSH）、促黄体生成素（LH）、催乳素、SmC/IGF - 1或皮质醇的血清浓度没有进一步升高。在患有肾衰竭的成年人中，生长激素似乎是唯一一种对其特定释放激素反应过度的垂体激素。
