INSERM, UMR, IFR, Lyon, France.
Bone. 2011 Jul;49(1):66-70. doi: 10.1016/j.bone.2010.11.017. Epub 2010 Dec 8.
Bisphosphonates, especially nitrogen-containing bisphosphonates, are widely used to block bone destruction in cancer patients with bone metastasis because they are effective inhibitors of osteoclast-mediated bone resorption. In addition to their antiresorptive effects, preclinical evidence strongly suggests that nitrogen-containing bisphosphonates exert direct and indirect anticancer activities through inhibition of tumor cell functions, enhancement of the cytotoxic activity of chemotherapy agents, inhibition of tumor angiogenesis, and stimulation of antitumor immune reactions. This review examines the current evidence and provides insights into ongoing preclinical research on anticancer activities of these bisphosphonates in animal models of tumorigenesis and metastasis.
双膦酸盐，尤其是含氮双膦酸盐，被广泛用于抑制癌症骨转移患者的骨质破坏，因为它们是破骨细胞介导的骨质吸收的有效抑制剂。除了抗吸收作用外，临床前证据强烈表明，含氮双膦酸盐通过抑制肿瘤细胞功能、增强化疗药物的细胞毒性活性、抑制肿瘤血管生成和刺激抗肿瘤免疫反应，发挥直接和间接的抗癌作用。本文综述了目前的证据，并深入探讨了这些双膦酸盐在肿瘤发生和转移动物模型中的抗癌活性的临床前研究进展。
