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Dysbindin and Schizophrenia: it's dopamine and glutamate all over again.

作者信息

Papaleo Francesco, Weinberger Daniel R

机构信息

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA.

出版信息

Biol Psychiatry. 2011 Jan 1;69(1):2-4. doi: 10.1016/j.biopsych.2010.10.028.

DOI:10.1016/j.biopsych.2010.10.028
PMID:21145442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3021467/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0c/3021467/790a58c8e5d8/nihms257212f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0c/3021467/790a58c8e5d8/nihms257212f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0c/3021467/790a58c8e5d8/nihms257212f1.jpg

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2
Dysbindin-1 and schizophrenia: from genetics to neuropathology.失调结合蛋白-1与精神分裂症:从遗传学到神经病理学
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Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.有证据表明,BLOC-1蛋白失调素可调节多巴胺D2受体的内化和信号传导,但不影响D1受体的内化。
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[Advances in the studies of the dysbindin gene in schizophrenia].[精神分裂症中失调素基因的研究进展]
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本文引用的文献

1
Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance.减少双调蛋白表达介导 N-甲基-D-天冬氨酸受体功能低下和工作记忆表现受损。
Biol Psychiatry. 2011 Jan 1;69(1):28-34. doi: 10.1016/j.biopsych.2010.09.012. Epub 2010 Oct 30.
2
Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways.Dysbindin-1 通过多巴胺/D2 途径调节前额叶皮层活动和类似精神分裂症的行为。
Mol Psychiatry. 2012 Jan;17(1):85-98. doi: 10.1038/mp.2010.106. Epub 2010 Oct 19.
3
Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study.沙鼠缺乏 dystonin 导致前额叶皮层多巴胺释放功能障碍:一项在体微透析研究。
Neurosci Lett. 2010 Feb 12;470(2):134-8. doi: 10.1016/j.neulet.2009.12.071. Epub 2010 Jan 5.
4
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.精神分裂症易感基因失调结合蛋白控制突触稳态。
Science. 2009 Nov 20;326(5956):1127-30. doi: 10.1126/science.1179685.
5
Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression.失调蛋白通过控制 NMDA 受体表面表达来调节海马长时程增强。
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21395-400. doi: 10.1073/pnas.0910499106. Epub 2009 Dec 1.
6
Role of dysbindin in dopamine receptor trafficking and cortical GABA function.失调结合蛋白在多巴胺受体转运及皮质γ-氨基丁酸功能中的作用
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19593-8. doi: 10.1073/pnas.0904289106. Epub 2009 Nov 3.
7
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.Dysbindin 调节前额叶皮层谷氨酸能回路和小鼠的工作记忆功能。
Neuropsychopharmacology. 2009 Nov;34(12):2601-8. doi: 10.1038/npp.2009.90. Epub 2009 Jul 29.
8
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.精神分裂症病例背外侧前额叶皮质中的双氢麦角胺-1 以与双氢麦角胺-1 mRNA 表达无关的亚型特异性方式减少。
Hum Mol Genet. 2009 Oct 15;18(20):3851-63. doi: 10.1093/hmg/ddp329. Epub 2009 Jul 19.
9
Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background.在C57BL/6J遗传背景下,dysbindin-1突变体sandy的神经行为异常。
Genes Brain Behav. 2009 Jun;8(4):390-7. doi: 10.1111/j.1601-183X.2009.00477.x. Epub 2009 Feb 11.
10
Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.有证据表明,BLOC-1蛋白失调素可调节多巴胺D2受体的内化和信号传导,但不影响D1受体的内化。
J Neurosci. 2007 Nov 7;27(45):12390-5. doi: 10.1523/JNEUROSCI.1689-07.2007.