MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK.
Trends Neurosci. 2011 Feb;34(2):101-12. doi: 10.1016/j.tins.2010.10.005. Epub 2010 Dec 9.
GABA(A) receptors in the CNS mediate both fast synaptic and tonic inhibition. Over the past decade a phasic current with features intermediate between fast synaptic and tonic inhibition, termed GABA(A,slow), has received increasing attention. This has coincided with an ever-growing appreciation for GABAergic cell type diversity. Compared with classical fast synaptic inhibition, GABA(A,slow) is slower by an order of magnitude. In this review, we summarize recent studies that have enhanced our understanding of GABA(A,slow). These include the discovery of specialized interneuron types from which this current originates, the factors that could underlie its characteristically slow kinetics, its contribution to specific aspects of integrative function and network oscillations, and its potential usefulness as a novel drug target for modulating inhibitory synaptic transmission in the CNS.
中枢神经系统中的 GABA(A) 受体介导快速突触和紧张性抑制。在过去的十年中,一种具有介于快速突触和紧张性抑制之间特征的相电流,称为 GABA(A,slow),越来越受到关注。这与对 GABA 能细胞类型多样性的认识不断增加是一致的。与经典的快速突触抑制相比,GABA(A,slow)慢一个数量级。在这篇综述中,我们总结了最近的研究,这些研究增强了我们对 GABA(A,slow)的理解。其中包括发现了产生这种电流的特定中间神经元类型,以及可能导致其特征性缓慢动力学的因素、它对整合功能和网络振荡特定方面的贡献,以及它作为调节中枢神经系统抑制性突触传递的新型药物靶点的潜在用途。