Program in Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada.
Trends Parasitol. 2011 Mar;27(3):131-40. doi: 10.1016/j.pt.2010.11.003. Epub 2010 Dec 8.
The phylum Apicomplexa comprises over 5000 species of obligate intracellular parasites, many responsible for diseases that significantly impact human health and economics. To aid drug development programs, global sequencing initiatives are generating increasing numbers of apicomplexan genomes. The challenge is how best to exploit these resources to identify effective therapeutic targets. Because of its important role in growth and maintenance, much interest has centred on metabolism. However, in the absence of detailed biochemical data, reconstructing the metabolic potential from a fully sequenced genome remains problematic. In this review current resources and tools facilitating the metabolic reconstruction for apicomplexans are examined. Furthermore, how these datasets can be utilized to explore the metabolic capabilities of apicomplexans are discussed and targets for therapeutic intervention are prioritized.
肉足鞭毛门包含超过 5000 种专性细胞内寄生虫，其中许多寄生虫可导致严重影响人类健康和经济的疾病。为了辅助药物开发项目，全球测序计划正在产生越来越多的肉足鞭毛门基因组。面临的挑战是如何最好地利用这些资源来确定有效的治疗靶点。由于其在生长和维持中的重要作用，代谢过程引起了广泛关注。然而，由于缺乏详细的生化数据，从完全测序的基因组中重建代谢潜能仍然存在问题。在这篇综述中，我们研究了促进肉足鞭毛门代谢重建的当前资源和工具。此外，还讨论了如何利用这些数据集来探索肉足鞭毛门的代谢能力，并对治疗干预的靶点进行了优先级排序。
