Ig 相关肾脏疾病在淋巴浆细胞疾病中的研究进展。

Ig-related renal disease in lymphoplasmacytic disorders: an update.

机构信息

Assistance Publique - Hôpitaux de Paris, Hôpital Tenon, Service de Néphrologie et Dialyses, Paris, France.

出版信息

Semin Nephrol. 2010 Nov;30(6):557-69. doi: 10.1016/j.semnephrol.2010.09.004.

DOI:10.1016/j.semnephrol.2010.09.004

Abstract

Ig-related renal diseases occurring in lymphoplasmacytic disorders (LPD) cover a wide spectrum of renal lesions. Except for cast nephropathy, which is almost specific for multiple myeloma, similar renal lesions caused by deposition or precipitation of monoclonal Ig-related material may occur in the various types of LPD. Because the secreted Ig provides the link between the LPD and the kidney disease, the renal outcome is linked to efficacy of chemotherapy. In the past 10 years, considerable advances have occurred in chemotherapy regimens with the advent of new classes of drugs, which already result in markedly improved renal and vital survival.

摘要

免疫球蛋白相关肾脏疾病发生在淋巴浆细胞疾病（LPD）中，涵盖了广泛的肾脏病变谱。除了几乎仅见于多发性骨髓瘤的管型肾病外，由单克隆免疫球蛋白相关物质沉积或沉淀引起的类似肾脏病变也可能发生在各种类型的 LPD 中。由于分泌的 Ig 为 LPD 和肾脏疾病之间提供了联系，因此肾脏的结局与化疗的疗效相关。在过去的 10 年中，随着新型药物类别的出现，化疗方案取得了相当大的进展，这已经显著改善了肾脏和总生存。